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Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1 ...
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Cytokinesis machinery promotes cell dissociation from collectively migrating strands in confinement | Science Advances
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The role of protein clearance mechanisms in organismal ageing and age-related diseases | Nature Communications
Polypharmacology by Design: A Medicinal Chemist's Perspective on Multitargeting Compounds | Journal of Medicinal Chemistry
Aberrant phase separation and nucleolar dysfunction in rare genetic diseases | Nature
Esophageal Webs and Rings: Background, Pathophysiology, Etiology
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Hematopoietic Progenitor Kinase 1 in Tumor Immunology: A Medicinal Chemistry Perspective | Journal of Medicinal Chemistry
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NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential | Signal Transduction and Targeted Therapy
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Discovery of TAK-041: a Potent and Selective GPR139 Agonist Explored for the Treatment of Negative Symptoms Associated with Schizophrenia | Journal of Medicinal Chemistry
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